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ALW-II-49-7

Chemical Structure : ALW-II-49-7

CAS No.: 1135219-23-6

ALW-II-49-7 (DDR2-IN-1)

Catalog No.: PC-62396Not For Human Use, Lab Use Only.

ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2).
ALW-II-49-7 displays excellent overall kinase selectivity against a panel of over 350 kinases.
ALW-II-49-7 decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines.

Physicochemical Properties

M.Wt 414.388
Formula C21H17F3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)nicotinamide

References

1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96.

2. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.

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