Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ALW-II-49-7
CAS No.: 1135219-23-6
Catalog No.: PC-62396Not For Human Use, Lab Use Only.
ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | $758 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2).
ALW-II-49-7 displays excellent overall kinase selectivity against a panel of over 350 kinases.
ALW-II-49-7 decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines.
| M.Wt | 414.388 | |
| Formula | C21H17F3N4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-((2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)nicotinamide |
|
1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96.
2. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
