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ALX-5407 hydrochloride

Chemical Structure : ALX-5407 hydrochloride

CAS No.: 200006-08-2

ALX-5407 hydrochloride (ALX5407)

Catalog No.: PC-62960Not For Human Use, Lab Use Only.

ALX-5407 hydrochloride is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.

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Biological Activity

ALX-5407 hydrochloride is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.
ALX-5407 has little or no activity at the GlyT2 transporter, at other binding sites for glycine, or at other neurotransmitter transporters.
ALX-5407 increases free glycine levels in rat prefrontal cortex (10 mg/kg, p.o.).

Physicochemical Properties

M.Wt 429.916
Formula C24H25ClFNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride

References

1. Atkinson BN, et al. Mol Pharmacol. 2001 Dec;60(6):1414-20.

2. Perry KW, et al. Neuropharmacology. 2008 Oct;55(5):743-54.

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