ALY688 | AdipoR agonist | Probechem Biochemicals

Chemical Structure : ALY688

ALY688 (ADP 355, ALY-688)

Catalog No.: PC-73202Not For Human Use, Lab Use Only.

ALY688 (ADP 355) is an adiponectin mimetic adiponectin receptor (AdipoR) agonist, inhibits the growth of AdipoR1/AdipoR2-positive cancer cell lines (MCF-7 cell, 0.1-10 uM).

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Biological Activity

ALY688 (ADP 355) is an adiponectin mimetic adiponectin receptor (AdipoR) agonist, inhibits the growth of AdipoR1/AdipoR2-positive cancer cell lines (MCF-7 cell, 0.1-10 uM).
ALY688 (ADP 355) differentially modulates AdipoR signaling pathways, increases the phosphorylation of AMPK, decreases ERK1/2 phosphorylation in MCF-7 cells.
ALY688 (ADP 355) inhibits the growth of MCF-7 xenografts in immunocompromised mice.
ALY688 (ADP 355) elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells.
ALY688 (ADP 355) promoted AMPK and acetyl-CoA carboxylase (ACC) phosphorylation, enhanced glucose oxidation, and suppressed fat oxidation in adipocytes from both fat depots.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	H-DAsn-Ile-Pro-Nva-Leu-Tyr-DSer-Phe-Ala-DSer-NH2

References

1. Laszlo Otvos Jr, et al. BMC Biotechnol. 2011 Oct 5;11:90.

2. Hye Kyoung Sung, et al. Am J Physiol Cell Physiol. 2022 Feb 1;322(2):C151-C163.

3. Da Eira D, et al. Adipocyte. 2020 Dec;9(1):550-562.

ALY688 (ADP 355, ALY-688)

Biological Activity

Physicochemical Properties

References

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