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AM-0466

Chemical Structure : AM-0466

CAS No.: 1642113-59-4

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AM-0466 (AM0466)

Catalog No.: PC-49224Not For Human Use, Lab Use Only.

AM-0464 (AM0464) is a highly potent, selective NaV1.7 inhibitor with IC50 of 21 nM, exhibits high levels of selectivity over other sodium channel isoforms (NaV1.5, IC50>30 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AM-0464 (AM0464) is a highly potent, selective NaV1.7 inhibitor with IC50 of 21 nM, exhibits high levels of selectivity over other sodium channel isoforms (NaV1.5, IC50>30 uM).
    AM-0464 demonstrates robust pharmacodynamic activity in a NaV1.7-dependent model of histamine-induced pruritus (itch) and additionally in a capsaicin-induced nociception model of pain without any confounding effect in open-field activity.

    Physicochemical Properties

    M.Wt 552.528
    Formula C27H19F3N4O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-methoxy-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-oxo-N-(pyrimidin-2-yl)-1,2-dihydroquinoline-6-sulfonamide

    References

    1. Russell F Graceffa, et al. J Med Chem. 2017 Jul 27;60(14):5990-6017.

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