Brimapitide (KU002, D-JNKI-1, XG-102, AM-111) is a cell-permeable peptide inhibitor of JNK kinases.
Brimapitide blocks apoptotic JNK signaling in brain mitochondria.
Brimapitide decreases the expression of CD4(+) and CD8(+) cells, effects T-cell activation, differentiation, and migration in a murine model of chronic colitis.
Brimapitide prevents hearing loss from SC transection in the guinea pig model of PA-OM.
Physicochemical Properties
M.Wt
3822.44
Formula
C164H286N66O40
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: >50 mg/mL
Chemical Name/SMILES
NH2-DQSRPVQPFLNLTTPRKPRPPRRRQRRKKRG-COOH
References
1. Eshraghi AA, et al. Otol Neurotol. 2006 Jun;27(4):504-11.
2. Zhao Y, et al. Mol Cell Neurosci. 2012 Mar;49(3):300-10.
3. Kersting S, et al. J Inflamm Res. 2013 May 3;6:71-81.
