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AM-2394

Chemical Structure : AM-2394

CAS No.: 1442684-77-6

AM-2394 (AM2394)

Catalog No.: PC-42091Not For Human Use, Lab Use Only.

AM-2394 (AM2394) is a potent, orally bioavailable Glucokinase (GK) activator with EC50 of 60 nM.

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2 mg (Free Sample) $28 In stock
10 mg $118 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AM-2394 (AM2394) is a potent, orally bioavailable Glucokinase (GK) activator with EC50 of 60 nM.
AM-2394 increases the affinity of GK for glucose by 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models.
AM-2394 lowers glucose excursion in an ob/ob mouse model of diabetes.

Physicochemical Properties

M.Wt 423.465
Formula C22H25N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-

References

1. Kohn TJ, et al. ACS Med Chem Lett. 2016 Jun 1;7(7):666-70.

2. Dransfield PJ, et al. ACS Med Chem Lett. 2016 May 23;7(7):714-8.

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