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Chemical Structure : AM-2394
CAS No.: 1442684-77-6
Catalog No.: PC-42091Not For Human Use, Lab Use Only.
AM-2394 (AM2394) is a potent, orally bioavailable Glucokinase (GK) activator with EC50 of 60 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $28 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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AM-2394 (AM2394) is a potent, orally bioavailable Glucokinase (GK) activator with EC50 of 60 nM.
AM-2394 increases the affinity of GK for glucose by 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models.
AM-2394 lowers glucose excursion in an ob/ob mouse model of diabetes.
| M.Wt | 423.465 | |
| Formula | C22H25N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl- |
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1. Kohn TJ, et al. ACS Med Chem Lett. 2016 Jun 1;7(7):666-70.
2. Dransfield PJ, et al. ACS Med Chem Lett. 2016 May 23;7(7):714-8.
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