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Chemical Structure : AM-6226
Catalog No.: PC-35199Not For Human Use, Lab Use Only.
AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.
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AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.
AM-6226 displays significant glucose lowering during an oral glucose tolerance test (OGTT) at 1 and 10 mg/kg in prediabetic cynomolgus monkeys.
| M.Wt | 522.633 | |
| Formula | C32H36F2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sean P. Brown, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med. Chem. Lett.,DOI: 10.1021/acsmedchemlett.8b00213
2. Luo J, et al. PLoS One. 2012;7(10):e46300.
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