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AM-6226

Chemical Structure : AM-6226

CAS No.: 1142222-28-3

AM-6226 (AM 6226;AM6226)

Catalog No.: PC-35199Not For Human Use, Lab Use Only.

AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AM-6226 (AM6226) is a potent, selective, orally bioavailable GPR40 (FFA1) full agonist with EC50 of 0.12 uM.
    AM-6226 displays significant glucose lowering during an oral glucose tolerance test (OGTT) at 1 and 10 mg/kg in prediabetic cynomolgus monkeys.

    Physicochemical Properties

    M.Wt 522.633
    Formula C32H36F2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-3-(3-((2-((R)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2-fluorophenyl)pentanoic acid

    References

    1. Sean P. Brown, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med. Chem. Lett.,DOI: 10.1021/acsmedchemlett.8b00213

    2. Luo J, et al. PLoS One. 2012;7(10):e46300.

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