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You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Beta-secretase (BACE)-AM-6494
AM-6494

Chemical Structure : AM-6494

CAS No.: 1874232-80-0

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AM-6494 (AM6494)

Catalog No.: PC-73095Not For Human Use, Lab Use Only.

AM-6494 (AM6494) is a potent and orally efficacious BACE1 inhibitor with IC50 of 0.4 nM, 47 fold selectivity over BACE2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AM-6494 (AM6494) is a potent and orally efficacious BACE1 inhibitor with IC50 of 0.4 nM, 47 fold selectivity over BACE2.
    Administration of AM-6494resulted in no skin/fur color change in a 13-day mouse hypopigmentation study.
    AM-6494 demonstrated robust and sustained reduction of CSF and brain Aβ40 levels in rat and monkey pharmacodynamic models.

    Physicochemical Properties

    M.Wt 473.499
    Formula C22H21F2N5O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-((1S,5S,6S)-3-Amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4,5-difluorophenyl)-5-(prop-2-yn-1-yloxy)pyrazine-2-carboxamide

    References

    1. Pettus LH, et al. J Med Chem. 2020 Mar 12;63(5):2263-2281.

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