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Chemical Structure : AM-6494
Catalog No.: PC-73095Not For Human Use, Lab Use Only.
AM-6494 (AM6494) is a potent and orally efficacious BACE1 inhibitor with IC50 of 0.4 nM, 47 fold selectivity over BACE2.
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AM-6494 (AM6494) is a potent and orally efficacious BACE1 inhibitor with IC50 of 0.4 nM, 47 fold selectivity over BACE2.
Administration of AM-6494resulted in no skin/fur color change in a 13-day mouse hypopigmentation study.
AM-6494 demonstrated robust and sustained reduction of CSF and brain Aβ40 levels in rat and monkey pharmacodynamic models.
| M.Wt | 473.499 | |
| Formula | C22H21F2N5O3S | |
| Appearance | Solid | |
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1. Pettus LH, et al. J Med Chem. 2020 Mar 12;63(5):2263-2281.
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