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AM-8123

Chemical Structure : AM-8123

CAS No.: 2049973-02-4

AM-8123 (AM8123)

Catalog No.: PC-38137Not For Human Use, Lab Use Only.

AM-8123 (AM8123) is a small-molecule agonist of Apelin receptor (APJ, APLNR), inhibits forskolin-stimulated cAMP production (pEC50=9.44) and promoted Gα protein activation (pEC50=8.95).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AM-8123 (AM8123) is a small-molecule agonist of Apelin receptor (APJ, APLNR), inhibits forskolin-stimulated cAMP production (pEC50=9.44) and promoted Gα protein activation (pEC50=8.95).

    Physicochemical Properties

    M.Wt 567.665
    Formula C27H33N7O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 1 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-

    References

    1. Brandon Ason, et al. JCI Insight. 2020 Apr 23;5(8):e132898.

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