AM-9514 | Glucokinase activator | Probechem Biochemicals

Chemical Structure : AM-9514

AM-9514 (AM 9514, AM9514)

Catalog No.: PC-61099Not For Human Use, Lab Use Only.

AM-9514 is a potent glucokinase (GK) activator with EC50 of 0.29 uM.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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Biological Activity

AM-9514 is a potent glucokinase (GK) activator with EC50 of 0.29 uM.
AM-9514 exhibits excellent solubility, permeability, in vitro clearances and free fractions in plasma protein binding.
AM-9514 demonstrates antidiabetic efficacy in vivo with no hypoglycemia.

Physicochemical Properties

M.Wt	359.43
Formula	C18H25N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-((1-ethyl-1H-pyrazol-5-yl)oxy)-5-(((1r,3s)-3-hydroxy-3-methylcyclobutyl)methyl)pyridin-2-yl)-3-methylurea

References

1. Du X, et al. ACS Med Chem Lett. 2014 Nov 22;5(12):1284-9.

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AM-9514 (AM 9514, AM9514)

Biological Activity

Physicochemical Properties

References

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