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Chemical Structure : AM432 sodium
Catalog No.: PC-61577Not For Human Use, Lab Use Only.
AM432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2.
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AM432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2.
AM432 shows no cross-reactivity against the TP or IP receptors, COX-1 or COX-2 and minimal activity at DP1 receptor.
AM432 shows excellent potency in a human whole blood eosinophil shape change assay.
AM432 exhibits efficacy in both a murine model of allergic rhinitis and a cigarette smoke induced inflammatory model of COPD.
| M.Wt | 511.574 | |
| Formula | C29H32N2NaO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stock N, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):1036-40.
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