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AM432 sodium

Chemical Structure : AM432 sodium

CAS No.: 1263409-34-2

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AM432 sodium (AM 432, AM-432)

Catalog No.: PC-61577Not For Human Use, Lab Use Only.

AM432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AM432 is potent, selective, orally active prostaglandin D2 receptor (DP2/CRTH2) antagonist with binding IC50 of 6 nM for hDP2.
    AM432 shows no cross-reactivity against the TP or IP receptors, COX-1 or COX-2 and minimal activity at DP1 receptor.
    AM432 shows excellent potency in a human whole blood eosinophil shape change assay.
    AM432 exhibits efficacy in both a murine model of allergic rhinitis and a cigarette smoke induced inflammatory model of COPD.

    Physicochemical Properties

    M.Wt 511.574
    Formula C29H32N2NaO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4'-(6-ethoxypyridin-3-yl)-2'-((N-ethylcyclopropanecarboxamido)methyl)-6-methoxy-[1,1'-biphenyl]-3-yl)acetic acid, sodium salt

    References

    1. Stock N, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):1036-40.

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