AM6580 | MAGL covalent inhibitor | Probechem Biochemicals

Chemical Structure : AM6580

AM6580 (AM-6580)

Catalog No.: PC-73016Not For Human Use, Lab Use Only.

AM6580 is a potent, covalent monoacylglycerol lipase (MAGL) inhibitor with IC50 of 3 nM (hMAGL).

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Biological Activity

AM6580 is a potent, covalent monoacylglycerol lipase (MAGL) inhibitor with IC50 of 3 nM (hMAGL).
AM6580 covalently binds to and inactivates MAGL by carbamylation of the enzyme's catalytic Ser122 nucleophile.

Physicochemical Properties

M.Wt	396.454
Formula	C23H20N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(9H-fluoren-9-yl)piperazin-1-yl)(1H-[1,2,3]triazolo[4,5-b]pyridin-1-yl)methanone

References

1. Benchama O, et al. Sci Rep. 2022 Mar 29;12(1):5328.

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AM6580 (AM-6580)

Biological Activity

Physicochemical Properties

References

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