Catalog No.: PC-61530Not For Human Use, Lab Use Only.
AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM).
AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM).
AMG-076 shows activity in reducing body weight in in vivo mouse models.
AMG-076 demonstrates good selectivity for MCHR1 and possesses good pharmacokinetic properties across preclinical species.
