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Chemical Structure : AMG-076
Catalog No.: PC-61530Not For Human Use, Lab Use Only.
AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM).
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AMG-076 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with binding IC50 of 0.6 nM, with dramatically reduced hERG liability (IC50>5 uM); shows activity in reducing body weight in in vivo mouse models, demonstrates good selectivity for MCHR1 and possesses good pharmacokinetic properties across preclinical species.
Obesity
Phase 1 Discontinued
| M.Wt | 462.557 | |
| Formula | C26H33F3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mihalic JT, et al. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3781-5.
2. Motani AS, et al. Pharmacol Res Perspect. 2013 Oct;1(1):e00003.
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