Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-c-Met (HGFR)-AMG-208
AMG-208

Chemical Structure : AMG-208

CAS No.: 1002304-34-8

Add to Favorites

AMG-208 (AMG208;AMG 208)

Catalog No.: PC-42849Not For Human Use, Lab Use Only.

AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM.

Packing Price Stock Quantity
5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM.
AMG-208 inhibits HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM.
AMG-208 suppresses proliferation and induces apoptosis in human tumor xenograft models.

Physicochemical Properties

M.Wt 383.4027
Formula C22H17N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: < 1 mg/mL
Chemical Name/SMILES

Quinoline, 7-methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]-

References

1. Hong DS, et al. Oncotarget. 2015 Jul 30;6(21):18693-706.

2. Albrecht BK, et al. J Med Chem. 2008 May 22;51(10):2879-82.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: