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AMG-208

Chemical Structure : AMG-208

CAS No.: 1002304-34-8

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AMG-208 (AMG208;AMG 208)

Catalog No.: PC-42849Not For Human Use, Lab Use Only.

AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM.
AMG-208 inhibits HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM.
AMG-208 suppresses proliferation and induces apoptosis in human tumor xenograft models.

Physicochemical Properties

M.Wt 383.4027
Formula C22H17N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: < 1 mg/mL
Chemical Name/SMILES

Quinoline, 7-methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]-

References

1. Hong DS, et al. Oncotarget. 2015 Jul 30;6(21):18693-706.

2. Albrecht BK, et al. J Med Chem. 2008 May 22;51(10):2879-82.

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