Catalog No.: PC-43024Not For Human Use, Lab Use Only.
AMG-3969 is a potent, metabolically stable Glucokinase (GK)-GKRP (GK regulatory protein) disruptor with IC50 of 4 nM, does not block the GK binding site directly.
AMG-3969 is a potent, metabolically stable Glucokinase (GK)-GKRP (GK regulatory protein) disruptor with IC50 of 4 nM, does not block the GK binding site directly.
AMG-3969 exhibits robust glucose lowering in diabetic mouse models.
AMG-3969 is highly effective in promoting carbohydrate substrate use, demonstrates a robust pharmacodynamic response (GK translocation, mGKGK translocation EC50=0.2 uM) as well as statistically significant dose-dependent reductions in fed blood glucose levels.
