AMG-397 | Mcl-1 inhibitor | Probechem Biochemicals

Chemical Structure : AMG-397

Catalog No.: PC-23835Not For Human Use, Lab Use Only.

Murizatoclax (AMG-397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor with Ki of 15 pM.

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Biological Activity

Murizatoclax (AMG-397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor with Ki of 15 pM.

M.Wt	765.45
Formula	C42H57ClN4O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3'R,4S,6'R,7'R,8'E,11'S,12'R)-7'-[[(9aR)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]methyl]-7-chloro-7'-methoxy-11',12'-dimethyl-13',13'-dioxospiro[2,3-dihydro-1H-naphthalene-4,22'-20-oxa-13λ6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene]-15'-one

1. Hargreaves D, et al. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2221967120.