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AMG-47a

Chemical Structure : AMG-47a

CAS No.: 882663-88-9

AMG-47a (AMG47a)

Catalog No.: PC-45449Not For Human Use, Lab Use Only.

AMG-47a is a potent Lck kinase inhibitor with IC50 of 0.2 nM, selectively reduces the levels of EGFP-KRASG12V protein but do not affect EGFP protein in cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AMG-47a is a potent Lck kinase inhibitor with IC50 of 0.2 nM, selectively reduces the levels of EGFP-KRASG12V protein but do not affect EGFP protein in cells.

Physicochemical Properties

M.Wt 535.5601
Formula C29H28F3N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name/SMILES

Benzamide, 4-methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]-

References

1. Carver J, et al. PLoS One. 2014 Aug 5;9(8):e103836.

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