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Chemical Structure : AMG-8718
Catalog No.: PC-61041Not For Human Use, Lab Use Only.
AMG-8718 is a potent, selective, orally active BACE1 inhibitor with IC50 of 0.7 nM, demonstrates limited selectivity for over BACE2 and high selectivity both renin and pepsin.
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AMG-8718 is a potent, selective, orally active BACE1 inhibitor with IC50 of 0.7 nM, demonstrates limited selectivity for over BACE2 and high selectivity both renin and pepsin.
BACE1 inhibitor demonstrates dose-dependent decreases in both CSF and brain Aβ levels in rat pharmacodynamic model, with significantly reduced potential for QTc elongation.
| M.Wt | 442.44 | |
| Formula | C25H19FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dineen TA, et al. J Med Chem. 2014 Dec 11;57(23):9811-31.
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