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Chemical Structure : AMG1
Catalog No.: PC-60979Not For Human Use, Lab Use Only.
AMG1 is a specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo.
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AMG1 is a specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo.
AMG1 potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM.
AMG1 strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively.
AMG1 shows potential for Th1/Th17-mediated autoimmune diseases.
| M.Wt | 413.732 | |
| Formula | C18H9ClF5N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85.
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