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AMG1

Chemical Structure : AMG1

CAS No.: 903591-53-7

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AMG1 (AMG 1;AMG-1)

Catalog No.: PC-60979Not For Human Use, Lab Use Only.

AMG1 is a specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AMG1 is a specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo.
    AMG1 potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM.
    AMG1 strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively.
    AMG1 shows potential for Th1/Th17-mediated autoimmune diseases.

    Physicochemical Properties

    M.Wt 413.732
    Formula C18H9ClF5N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(2-chloro-5-(trifluoromethyl)phenyl)-2-pyrazinyl)-2,6-difluorobenzamid

    References

    1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85.

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