AMG 579 | PDE10A inhibitor | Probechem Biochemicals

Chemical Structure : AMG 579

CAS No.: 1227067-61-9

AMG 579 (AMG-579, AMG579)

Catalog No.: PC-60496Not For Human Use, Lab Use Only.

AMG 579 (AMG579) is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
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Biological Activity

AMG 579 (AMG579) is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM.
AMG-579 displays high selectivity with IC50 > 30 uM against all other PDE isoforms.
AMG-579 demonstrates excellent target occupancy efficacy in PCP-LMA behavioral model.

Physicochemical Properties

M.Wt	441.491
Formula	C25H23N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone

References

1. Hu E, et al. J Med Chem. 2014 Aug 14;57(15):6632-41.

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AMG 579 (AMG-579, AMG579)

Biological Activity

Physicochemical Properties

References

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