You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-AMG 580
AMG 580

Chemical Structure : AMG 580

CAS No.: 1227067-71-1

AMG 580 (AMG-580;AMG580)

Catalog No.: PC-60651Not For Human Use, Lab Use Only.

AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM.

Packing Price Stock Quantity
25 mg Get quote
100 mg Get quote
250 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM.
    AMG 580 displays no activity against PED isoforms at 30 uM.
    AMG 580 is suitable as a tracer for lead optimization to determine target coverage by novel PDE10A inhibitors.
    AMG 580 shows potential imaging biomarker for mapping PDE10A distribution and ensuring target coverage by therapeutic PDE10A inhibitors in clinical studies.

    Physicochemical Properties

    M.Wt 473.508
    Formula C26H24FN5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)-2-fluoropropan-1-one

    References

    1. Chen H, et al. J Pharmacol Exp Ther. 2015 Feb;352(2):327-37.

    2. Hu E, et al. ACS Med Chem Lett. 2016 May 19;7(7):719-23.

    3. Hwang DR, et al. Nucl Med Biol. 2015 Aug;42(8):654-63.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: