AMG 580 |CAS:1227067-71-1 Probechem Biochemicals

Chemical Structure : AMG 580

AMG 580 (AMG-580;AMG580)

Catalog No.: PC-60651Not For Human Use, Lab Use Only.

AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM.

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Biological Activity

AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM.
AMG 580 displays no activity against PED isoforms at 30 uM.
AMG 580 is suitable as a tracer for lead optimization to determine target coverage by novel PDE10A inhibitors.
AMG 580 shows potential imaging biomarker for mapping PDE10A distribution and ensuring target coverage by therapeutic PDE10A inhibitors in clinical studies.

Physicochemical Properties

M.Wt	473.508
Formula	C26H24FN5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)-2-fluoropropan-1-one

References

1. Chen H, et al. J Pharmacol Exp Ther. 2015 Feb;352(2):327-37.

2. Hu E, et al. ACS Med Chem Lett. 2016 May 19;7(7):719-23.

3. Hwang DR, et al. Nucl Med Biol. 2015 Aug;42(8):654-63.

AMG 580 (AMG-580;AMG580)

Biological Activity

Physicochemical Properties

References

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