AMG747 | GlyT1 inhibitor | Probechem Biochemicals

Chemical Structure : AMG747

AMG747 (Tilapertin, AMG-747)

Catalog No.: PC-60977Not For Human Use, Lab Use Only.

AMG747 (Tilapertin) is a nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.

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Biological Activity

AMG747 (Tilapertin) is a nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.
AMG747 (Tilapertin) dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats and humans.

Physicochemical Properties

M.Wt	378.395
Formula	C20H21F3N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperazineacetic acid, 4-[(R)-phenyl[3-(trifluoromethyl)phenyl]methyl]-

References

1. Dunayevich E, et al. Schizophr Res. 2017 Apr;182:90-97.

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AMG747 (Tilapertin, AMG-747)

Biological Activity

Physicochemical Properties

References

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