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AMG747

Chemical Structure : AMG747

CAS No.: 1000690-85-6

AMG747 (Tilapertin, AMG-747)

Catalog No.: PC-60977Not For Human Use, Lab Use Only.

AMG747 (Tilapertin) is a nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AMG747 (Tilapertin) is a nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia.
    AMG747 (Tilapertin) dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats and humans.

    Physicochemical Properties

    M.Wt 378.395
    Formula C20H21F3N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-Piperazineacetic acid, 4-[(R)-phenyl[3-(trifluoromethyl)phenyl]methyl]-

    References

    1. Dunayevich E, et al. Schizophr Res. 2017 Apr;182:90-97.

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