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AMP945

Chemical Structure : AMP945

CAS No.: 1393653-34-3

AMP945 (Narmafotinib, CTX-0294945)

Catalog No.: PC-20058Not For Human Use, Lab Use Only.

Narmafotinib (AMP945, CTX-0294945) is a potent, selective and orally bioavailable Focal Adhesion Kinase (FAK) inhibitor with IC50 of 2.2 nM, >200-fold selectivity over Pyk2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Narmafotinib (AMP945, CTX-0294945) is a potent, selective and orally bioavailable Focal Adhesion Kinase (FAK) inhibitor with IC50 of 2.2 nM, >200-fold selectivity over Pyk2.
AMP945 is highly selective for FAK across 468 kinase screening.
AMP945 shows potential for the treatment of pancreatic cancer in combination with standard of care gemcitabine and nab-paclitaxel.

Physicochemical Properties

M.Wt 527.59
Formula C28H32F3N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[2-[2-[[2-Methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]ethyl]benzeneacetamide

References

1. John Lambert, et al. Cancer Res (2022) 82 (22_Supplement): A015.

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