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AMR-2

Chemical Structure : AMR-2

CAS No.: 877244-97-8

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AMR-2 (AMR2)

Catalog No.: PC-63567Not For Human Use, Lab Use Only.

AMR-2 is a highly potent, orally active, triple reuptake inhibitor of SERT, NET, and DAT with IC50 of 3.0, 3.1, and 8.3 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AMR-2 is a highly potent, orally active, triple reuptake inhibitor of SERT, NET, and DAT with IC50 of 3.0, 3.1, and 8.3 nM, respectively.
    AMR-2 showed efficacy in the rat forced-swim and mouse tail suspension models with minimum effective doses of 0.3 and 1 mg/kg (po),.
    AMR-2 exhibits substantial occupancy levels at the three transporters in both rat and mouse brain.

    Physicochemical Properties

    M.Wt 364.507
    Formula C22H24N2OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-(4-(benzo[b]thiophen-5-yl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)morpholine

    References

    1. Liu S, et al. ACS Med Chem Lett. 2014 May 13;5(7):760-5.

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