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Chemical Structure : AMR-2
Catalog No.: PC-63567Not For Human Use, Lab Use Only.
AMR-2 is a highly potent, orally active, triple reuptake inhibitor of SERT, NET, and DAT with IC50 of 3.0, 3.1, and 8.3 nM, respectively.
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AMR-2 is a highly potent, orally active, triple reuptake inhibitor of SERT, NET, and DAT with IC50 of 3.0, 3.1, and 8.3 nM, respectively; showed efficacy in the rat forced-swim and mouse tail suspension models with minimum effective doses of 0.3 and 1 mg/kg (po), exhibits substantial occupancy levels at the three transporters in both rat and mouse brain.
| M.Wt | 364.507 | |
| Formula | C22H24N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu S, et al. ACS Med Chem Lett. 2014 May 13;5(7):760-5.
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