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AN-12-H5

Chemical Structure : AN-12-H5

CAS No.: 1193340-31-6

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AN-12-H5 (Enterovirus inhibitor)

Catalog No.: PC-62927Not For Human Use, Lab Use Only.

AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM.
    Mutations in capsid proteins (G3112A, VP1-Ala224Thr, and G2396A, VP3-Arg227Lys mutations) are resistant to AN-12-H5.

    Physicochemical Properties

    M.Wt 513.645
    Formula C24H23N3O4S3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((6aS,8S)-2-(4-(methylthio)phenyl)-6,12-dioxo-5,6,6a,7,8,9,10,12-octahydrobenzo[e]pyrido[1,2-a][1,4]diazepin-8-yl)thiophene-2-sulfonamide

    References

    1. Arita M, et al. J Gen Virol. 2010 Nov;91(Pt 11):2734-44.

    2. Arita M, et al. J Virol. 2011 Mar;85(5):2364-72.

    3. Arita M, et al. J Virol. 2013 Apr;87(8):4252-60.

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