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Chemical Structure : AN2718
CAS No.: 174672-06-1
Catalog No.: PC-22624Not For Human Use, Lab Use Only.
AN2718 is a small molecule inhibitor of the catalytic activity of the Klebsiella pneumoniae carbapenemase (KPC-2) enzyme with IC50 of 0.5 uM and ITC Kd of 86.3 nM, exhibit synergistic antimicrobial effect with Meropenem.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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AN2718 is a small molecule inhibitor of the catalytic activity of the Klebsiella pneumoniae carbapenemase (KPC-2) enzyme with IC50 of 0.5 uM and ITC Kd of 86.3 nM, exhibit synergistic antimicrobial effect with Meropenem.
AN2718 is an effective antimicrobial agent that can eradicate KPC-2 strains in vitro.
AN2718 can disrupt the homeostasis of energy metabolism by altering the NAD/NADH ratio and affecting ATP production, thereby blocking bacteria from growing.
AN2718 restores the antimicrobial activity of Meropenem in the treatment of carbapenem resistant infections in vivo.
| M.Wt | 168.38 | |
| Formula | C7H6BClO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole |
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1. Tang Y, et al. Int J Antimicrob Agents. 2024 Jul 5:107268.
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