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Chemical Structure : AN317
Catalog No.: PC-49027Not For Human Use, Lab Use Only.
AN317 is a functionally selective, partial agonist of α6β2-containing nicotinic acetylcholine receptor (nAChR) with pEC50 of 7.17 (α6/α3β2β3V9'S receptor) in cell-based assays, inhibits the effect of nicotine with IC50 of 1.1 uM.
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AN317 is a functionally selective, partial agonist of α6β2-containing nicotinic acetylcholine receptor (nAChR) with pEC50 of 7.17 (α6/α3β2β3V9'S receptor) in cell-based assays, inhibits the effect of nicotine with IC50 of 1.1 uM.
AN317 displays functional selectivity toward other nAChRs, including α4β2, α3β4 and α7 receptors.
AN317 induced [3H]dopamine release from rat striatal synaptosomes and augmented dopaminergic neuron activity in substantia nigra pars compacta brain slices in Ca2+ imaging and electrophysiological assays.
AN317 alleviated the high-frequency tremors arising from reserpine-mediated dopamine depletion in rats.
AN317 mediated significant protective effects on cultured rat mesencephalic neurons treated with the dopaminergic neurotoxin MPP+.
AN317 displays good bioavailability and readily crosses the blood-brain barrier for in vivo research.
| M.Wt | 217.316 | |
| Formula | C13H19N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sandager-Nielsen K, et al. Biochem Pharmacol. 2020 Apr;174:113786.
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