Catalog No.: PC-43064Not For Human Use, Lab Use Only.
ANA-12 (Ana12) is a selective TrkB antagonist that binds TrkB ECD-Fc with Kd of 12 uM, prevents BDNF-induced neurite outgrowth (at 10 nM), inhibits processes downstream of TrkB without altering TrkA and TrkC functions.
ANA-12 (Ana12) is a selective TrkB antagonist that binds TrkB ECD-Fc with Kd of 12 uM, prevents BDNF-induced neurite outgrowth (at 10 nM), inhibits processes downstream of TrkB without altering TrkA and TrkC functions.
ANA-12 decreases TrkB activity in the brain without affecting neuronal survival, anxiolytic and antidepressant activity in mice.
