ANI-7 | AhR agonist | Probechem Biochemicals

Chemical Structure : ANI-7

CAS No.: 931417-26-4

ANI-7 (ANI 7;ANI7)

Catalog No.: PC-60774Not For Human Use, Lab Use Only.

ANI-7 is a potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway.

Packing	Price	Stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

ANI-7 is a potent and selective (up to 263-fold) inhibitor of breast cancer cells with GI50 of 0.5 uM (MCF-7), via activation the aryl hydrocarbon receptor (AhR) pathway.
ANI-7 inhibits other cell lines derived from other tumour types with GI50 of 3.2-46 uM (lung, colon, ovary, neuronal, glial, prostate, and pancreas).
ANI-7 potently inhibits the growth of T47D, ZR-75-1, MCF-7, SKBR3, and MDA-MB-468 breast cancer cells with GI50 of 0.16-0.38 uM, induces cell cycle arrest checkpoint activation and DNA damage.
ANI-7 binds to the AhR, induces translocation to the nucleus, activates the XRE, induces CYP1 activity, culminating in cell cycle arrest, checkpoint activation, DNA damage and cell death.

Physicochemical Properties

M.Wt	263.121
Formula	C13H8Cl2N2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(3,4-dichlorophenyl)-3-(1H-pyrrol-2-yl)acrylonitrile

References

1. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.

ANI-7 (ANI 7;ANI7)

Biological Activity

Physicochemical Properties

References

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