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Chemical Structure : ANP-230
CAS No.: 1233231-30-5
Catalog No.: PC-22424Not For Human Use, Lab Use Only.
ANP-230 (DSP-2230) is a selective sodium channel blocker of human Nav1.7, Nav1.8, and Nav1.9 with IC50 of 7.1, 11.4, and 6.7 μM (sodium currents), shows only low inhibitory activity to human cardiac Nav1.5 channel and rat central Nav channels.
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|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
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ANP-230 (DSP-2230) is a selective sodium channel blocker of human Nav1.7, Nav1.8, and Nav1.9 with IC50 of 7.1, 11.4, and 6.7 μM (sodium currents), shows only low inhibitory activity to human cardiac Nav1.5 channel and rat central Nav channels.
ANP-230 shows comparable potency and selectivity when evaluated by manual patch-clamp technique (IC50 values for Nav1.7, Nav1.8, and Nav1.5 were 9.3, 5.5, and 151.2 μM, respectively.
ANP-230 causes a depolarizing shift of the activation curve for peripheral Nav channels and decelerates the gating kinetics of Nav1.7.
ANP-230 (10, 30 uM) potently reduces neuronal excitability in rat DRG neurons.
| M.Wt | 419.41 | |
| Formula | C20H20F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-(((3-Cyclobutyl-5-(3,4,5-trifluorophenoxy)-3H-imidazo[4,5-b]pyridin-2-yl)methyl)amino)propanamide |
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1. Kamei T, et al. Biochem Biophys Res Commun. 2024 May 14;721:150126.
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