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Chemical Structure : AOH1160
CAS No.: 2089314-57-6
Catalog No.: PC-35301Not For Human Use, Lab Use Only.
AOH1160 (AOH-1160) is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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AOH1160 (AOH-1160) is a potent, first-in-class, orally available small molecule inhibitor of Proliferating cell nuclear antigen (PCNA).
AOH1160 selectively kills many types of cancer cells at below micromolar concentrations (mean GI50=330 nM) without causing significant toxicity to a broad range of non-malignant cells, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, and causes cell cycle arrest.
AOH1160 suppresses tumor growth without causing significant side effects in mice, demostrates the potential as a broad-spectrum therapeutic agent for cancer treatment.
| M.Wt | 396.446 | |
| Formula | C25H20N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(2-oxo-2-((2-phenoxyphenyl)amino)ethyl)-1-naphthamide |
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1. Gu L, et al. Clin Cancer Res. The anti-cancer activity of a first-in-class small molecule targeting PCNA. 2018 Jul 2. pii: clincanres.0592.2018.
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