Catalog No.: PC-25819Not For Human Use, Lab Use Only.
AP232 (AP-232) is a specific small molecule splicing factor U2AF1-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM).
AP232 (AP-232) is a specific small molecule splicing factor U2AF1-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM).
AP232 has 31-fold improvement in the IC50 value than SF153 (Cat# PC-25479) against U2AF1-UHM based on the HTRF assay.
AP232 potently inhibits growth in HNT-34 (IC50 = 6.49 ± 0.38 μM) and MONO-MAC-1 (IC50 = 14.09 uM).
AP232 (20 uM) 2markedly increased the G2/M population in NKM-1 cells at 48 h.
AP232 impares lysosome acidification and autophagy in leukemia cells.
