Chemical Structure : AP232 dihydrochloride
CAS No.:
AP232 dihydrochloride
(AP-232 dihydrochloride)
Catalog No.: PC-28202Not For Human Use, Lab Use Only.
AP232 dihydrochloride (AP-232) is a specific small molecule splicing factor U2AF1-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AP232 dihydrochloride (AP-232) is a specific small molecule splicing factor U2AF1-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM).
AP232 has 31-fold improvement in the IC50 value than SF153 (Cat# PC-25479) against U2AF1-UHM based on the HTRF assay.
AP232 potently inhibits growth in HNT-34 (IC50 = 6.49 ± 0.38 μM) and MONO-MAC-1 (IC50 = 14.09 uM).
AP232 (20 uM) 2markedly increased the G2/M population in NKM-1 cells at 48 h.
AP232 impares lysosome acidification and autophagy in leukemia cells.
Physicochemical Properties
|
M.Wt
|
402.40
|
|
Formula
|
C20H33Cl2N3O
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-Piperidinamine, 1-[3-(4-ethoxy-1H-indol-3-yl)-1-methylpropyl]-4-methyl- dihydrochloride
|
References
1. Patil AD, et al. ACS Med Chem Lett. 2025 Sep 11;16(10):2015-2021.
Contact Us
sales@probechem.com
