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APJ agonist 47

Chemical Structure : APJ agonist 47

CAS No.: 2100849-17-8

APJ agonist 47

Catalog No.: PC-38748Not For Human Use, Lab Use Only.

APJ agonist 47 is a potent and selective, orally active apelin receptor (APJ) agonist EC50 of 6.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    APJ agonist 47 is a potent and selective, orally active apelin receptor (APJ) agonist EC50 of 6.5 nM.
    APJ agonist 47 has vastly reduced brain penetration and is devoid of significant off-target liability.
    APJ agonist 47 is suitable for in vivo studies of APJ in peripheral tissues after oral administration.

    Physicochemical Properties

    M.Wt 566.581
    Formula C26H31F5N8O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-1-cyclopentyl-N-(4-(3,3-difluoropiperidin-1-yl)-1-(1H-tetrazol-5-yl)butan-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxamide

    References

    1. Sanju Narayanan, et al. Bioorg Med Chem. 2022 May 6;66:116789.

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