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APJ agonist 47

Chemical Structure : APJ agonist 47

CAS No.: 2100849-17-8

APJ agonist 47

Catalog No.: PC-38748Not For Human Use, Lab Use Only.

APJ agonist 47 is a potent and selective, orally active apelin receptor (APJ) agonist EC50 of 6.5 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

APJ agonist 47 is a potent and selective, orally active apelin receptor (APJ) agonist EC50 of 6.5 nM.
APJ agonist 47 has vastly reduced brain penetration and is devoid of significant off-target liability.
APJ agonist 47 is suitable for in vivo studies of APJ in peripheral tissues after oral administration.

Physicochemical Properties

M.Wt 566.581
Formula C26H31F5N8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-cyclopentyl-N-(4-(3,3-difluoropiperidin-1-yl)-1-(1H-tetrazol-5-yl)butan-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxamide

References

1. Sanju Narayanan, et al. Bioorg Med Chem. 2022 May 6;66:116789.

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