Chemical Structure : APTO-253
CAS No.: 916151-99-0
Catalog No.: PC-35075Not For Human Use, Lab Use Only.
APTO-253 (LOR-253) is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.
Packing | Price | Stock | Quantity |
---|---|---|---|
1 mg (Free Sample) | $28 | In stock | |
10 mg | $118 | In stock | |
25 mg | $198 | In stock | |
50 mg | $328 | In stock | |
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
APTO-253 (LOR-253) is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.
APTO-253 is converted intracellularly from a monomer to a ferrous complex [Fe(253)3].
APTO-253 selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species and humans, induces DNA Damage in AML cells.
M.Wt | 367.387 | |
Formula | C22H14FN5 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
2-(5-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline |
1. Tsai CY, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-0834.
2. Cercek A, et al. Invest New Drugs. 2015 Oct;33(5):1086-92.
3. Wang B, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):486-492.
4. Local A, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-1209.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright