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Chemical Structure : APTO-253 hydrochloride
Catalog No.: PC-35076Not For Human Use, Lab Use Only.
APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels.
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APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels; APTO-253 is converted intracellularly from a monomer to a ferrous complex [Fe(253)3]; selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells without producing myelosuppression in various animal species and humans, induces DNA Damage in AML cells.
Blood Cancer
Phase 1 Clinical
| M.Wt | 403.845 | |
| Formula | C22H15ClFN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tsai CY, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-0834.
2. Cercek A, et al. Invest New Drugs. 2015 Oct;33(5):1086-92.
3. Wang B, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):486-492.
4. Local A, et al. Mol Cancer Ther. 2018 Apr 6. doi: 10.1158/1535-7163.MCT-17-1209.
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