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APX2014

Chemical Structure : APX2014

CAS No.: 1415030-17-9

APX2014 (APX 2014;APX-2014)

Catalog No.: PC-35563Not For Human Use, Lab Use Only.

APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition.

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    Biological Activity

    APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition.
    APX2014 inhibits endothelial cell proliferation in HRECs and Rf/6a cells in vitro with GI50 of 0.11 and 5 uM, respectively.
    APX2014 significantly inhibits endothelial tube formation in HRECs and Rf/6a cells in vitro, inhibits TNF-α mediated NF-κB signaling and proangiogenic target gene mRNA expression.
    APX2014 inhibits choroidal sprouting at high nanomolar concentrations in ex vivo, blocks ocular angiogenesis in vitro and ex vivo.

    Physicochemical Properties

    M.Wt 329.352
    Formula C18H19NO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-N-methoxy-2-((3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylene)pentanamide

    References

    1. Sardar Pasha SPB, et al. J Pharmacol Exp Ther. 2018 Aug 3. pii: jpet.118.248088.

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