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Chemical Structure : AQW-051
Catalog No.: PC-61600Not For Human Use, Lab Use Only.
AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56.
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AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56; displays high selectivity (>100-fold) over other nACh receptors; stimulates calcium influx in GH3–ha7-22 cells recombinantly expressing the human α7-nACh receptor with pEC50 of 7.41; facilitates learning/memory performance in mice; reduces l-Dopa-induced dyskinesias and extends the duration of l-Dopa effects in parkinsonian monkeys.
Parkinson Disease
Phase 2 Clinical
| M.Wt | 294.398 | |
| Formula | C19H22N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Feuerbach D, et al. Br J Pharmacol. 2015 Mar;172(5):1292-304.
2. Di Paolo T, et al. Parkinsonism Relat Disord. 2014 Nov;20(11):1119-23.
3. Beinat C, et al. CNS Drugs. 2015 Jul;29(7):529-42.
4. Trenkwalder C, et al. Mov Disord. 2016 Jul;31(7):1049-54.
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