Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AR-42
CAS No.: 935881-37-1
Catalog No.: PC-60407Not For Human Use, Lab Use Only.
AR-42 (HDAC-42, OSU-HDAC42, NSC-D736012) is a potent pan-HDAC inhibitor with IC50 of 16-30 nM, inhibits cell proliferation of P815, C2, and BR cells with IC50 of 0.65, 0.30, and 0.23 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AR-42 (HDAC-42, OSU-HDAC42, NSC-D736012) is a potent pan-HDAC inhibitor with IC50 of 16-30 nM, inhibits cell proliferation of P815, C2, and BR cells with IC50 of 0.65, 0.30, and 0.23 uM, respectively.
AR-42 promotes hyperacetylation of H3, H4, and α-tubulin, and up-regulation of p21, also down-regulates the expression of p-Akt, total Akt, pSTAT3/5, and total STAT3/5.
AR-42 increases response to decitabine treatment via upregulation of miR-29b.
AR-42 prolongs survival in an ATL NOD/SCID mouse model.
| M.Wt | 312.36 | |
| Formula | C18H20N2O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(S)-(+)-N-hydroxy-4-(3-methyl-2-phenyl-butyrylamino) benzamide |
|
1. Lin TY, et al. Blood. 2010 May 27;115(21):4217-25.
2. Sargeant AM, et al. Cancer Res. 2008 May 15;68(10):3999-4009.
3. Mims A, et al. Leukemia. 2013 Apr;27(4):871-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
