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AR-C102222

Chemical Structure : AR-C102222

CAS No.: 253771-21-0

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AR-C102222 (AR-C 102222)

Catalog No.: PC-62230Not For Human Use, Lab Use Only.

AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively.
    AR-C102222 reduces inflammation produced by the application of arachidonic acid to the ear, attenuates FCA-induced mechanical hyperalgesia, and attenuates acetic acid-induced writhing in mice.

    Physicochemical Properties

    M.Wt 382.375
    Formula C19H16F2N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Spiro[piperidine-4,2'(1'H)-quinazolin]-4'-amine, 1-[(6-cyano-3-pyridinyl)carbonyl]-5',8'-difluoro- (9CI)

    References

    1. Garcin ED, et al. Nat Chem Biol. 2008 Nov;4(11):700-7.

    2. Tinker AC, et al. J Med Chem. 2003 Mar 13;46(6):913-6.

    3. LaBuda CJ, et al. Eur J Pain. 2006 Aug;10(6):505-12.

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