AR-C155858 (ARC155858)

Chemical Structure : AR-C155858

CAS No.: 496791-37-8

Catalog No.: PC-43427Not For Human Use, Lab Use Only.

AR-C155858 is a potent monocarboxylate transporter MCT1 and MCT2 with Ki of 2.3 nM and <10 nM, displays no activity at MCT4.

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5 mg	$258	In stock
10 mg	$428	In stock
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Biological Activity

AR-C155858 is a potent monocarboxylate transporter MCT1 and MCT2 with Ki of 2.3 nM and <10 nM, displays no activity at MCT4.
AR-C155858 inhibits glycolysis and glutathione synthesis, inhibits tumor cell proliferation.
AR-C155858 suppresses lactate export, glycolysis, and tumor growth by blocking MCT1/2 in Ras-transformed fibroblasts.

Physicochemical Properties

M.Wt	461.5346
Formula	C21H27N5O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-

References

1. Ovens MJ, et al. Biochem J. 2010 Jan 15;425(3):523-30.

2. Ovens MJ, et al. Biochem J. 2010 Oct 15;431(2):217-25.

3. Le Floch R, et al. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16663-8.

4. Doherty JR, et al. Cancer Res. 2014 Feb 1;74(3):908-20.