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AR-HO47108

Chemical Structure : AR-HO47108

CAS No.: 248281-68-7

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AR-HO47108 (AR HO47108)

Catalog No.: PC-62959Not For Human Use, Lab Use Only.

AR-HO47108 is a potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 7.0.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AR-HO47108 is a potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 7.0.
    AR-HO47108 shows efficacy in animal models of gastric acid secretion.

    Physicochemical Properties

    M.Wt 336.439
    Formula C20H24N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-((2-ethyl-6-methylbenzyl)amino)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide

    References

    1. Abelö A, et al. Eur J Pharm Sci. 2006 Oct 1;29(2):91-101. Epub 2006 Jun 9.

    2. Bailey N, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6.

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