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ARC-3140

Chemical Structure : ARC-3140

CAS No.: 1795733-65-1

ARC-3140 (ARC3140)

Catalog No.: PC-22273Not For Human Use, Lab Use Only.

ARC-3140 is a potent, selective bisubstrate inhibitor of protein kinase CK2 (Casein kinase II) with Ki of 84 pM, addressing the ATP site and the substrate-binding site of CK2, interferes with both sub-interfaces of the bipartite CK2α/CK2β interaction.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ARC-3140 is a potent, selective bisubstrate inhibitor of protein kinase CK2 (Casein kinase II) with Ki of 84 pM, addressing the ATP site and the substrate-binding site of CK2, interferes with both sub-interfaces of the bipartite CK2α/CK2β interaction.

Physicochemical Properties

M.Wt 1582.63
Formula C45H58I4N10O21
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(8-(4,5,6,7-tetraiodo-1H-benzo[d]imidazol-1-yl)octanoyl)-D-aspartyl-L-aspartyl-L-aspartyl-L-aspartyl-L-aspartyl-L-aspartyl-L-lysine

References

1. Markus Pietsch, et al. Bioorg Chem. 2020 Mar:96:103608.

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