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Chemical Structure : ARC 239 dihydrochloride
CAS No.: 55974-42-0
Catalog No.: PC-60704Not For Human Use, Lab Use Only.
ARC 239 dihydrochloride is a potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors.
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|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $268 | In stock | |
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ARC 239 dihydrochloride is a potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors.
ARC 239 competitively antagonizes pressor responses to adrenaline and inhibits pressor responses to noradrenaline, phenylephrine, tyramine, and dimethylphenylpiperazinium in rats and dogs.
| M.Wt | 480.43 | |
| Formula | C24H29N3O3.2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride |
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1. Mouillé P, et al. J Cardiovasc Pharmacol. 1980;2(2):175-91.
2. Bylund D, et al. J Pharmacol Exp Ther. 1988 May;245(2):600-7.
3. Bylund DB, et al. J Pharmacol Exp Ther. 1989 Nov;251(2):640-4.
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