ARCher-142 | TNKS2 ARC4 inhibitor | Probechem Biochemicals

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Chemical Structure : ARCher-142

ARCher-142 (TNKS2 ARC4 inhibitor S8)

Catalog No.: PC-25988Not For Human Use, Lab Use Only.

ARCher-142 (S8/ARCher-142) is a specific TNKS2 ARC4 inhibitor that specifically targeting the ARC4 peptide binding domain, binds selectively to TNKS2 ARC4 with a potency of 8 uM, attenuates the WNT/β-catenin pathway in cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	466.53
Formula	C26H30N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(diethylamino)propyl)-4-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbonyl)-3-hydroxy-5-(4-hydroxyphenyl)-1,5-dihydro-2H-pyrrol-2-one

References

1. Bosetti C, et al. Structure. 2026 Jan 30:S0969-2126(25)00496-4.

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ARCher-142 (TNKS2 ARC4 inhibitor S8)

Biological Activity

Physicochemical Properties

References

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