ARM165 | PIK3CG/p110γ degrader | Probechem Biochemicals

Chemical Structure : ARM165

ARM165 (ARM-165)

Catalog No.: PC-22441Not For Human Use, Lab Use Only.

ARM165 is a proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically degrades PIK3CG/p110γ, specifically degrades PIK3CG and potently suppresses AML.

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Biological Activity

ARM165 is a proteolysis-targeting chimera (PROTAC) heterobifunctional molecule that specifically degrades PIK3CG/p110γ, specifically degrades PIK3CG and potently suppresses AML.

Physicochemical Properties

M.Wt	837.99
Formula	C44H51N7O8S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(5-(2-((S)-1-cyclopropylethyl)-7-methyl-1-oxoisoindolin-5-yl)-4-methylthiazol-2-yl)-N5-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-8-oxooctyl)glutaramide

References

1. Kelly LM, et al. Nat Cancer. 2024 May 30. doi: 10.1038/s43018-024-00782-5.

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ARM165 (ARM-165)

Biological Activity

Physicochemical Properties

References

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