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Chemical Structure : ARN-21934
CAS No.: 2230854-93-8
Catalog No.: PC-38577Not For Human Use, Lab Use Only.
ARN-21934 is a potent, highly selective human topoisomerase II α (Topo IIα) with IC50 of 2 μM for inhibition of DNA relaxation, 100-fold selectivity for topo IIα over Topo β.
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ARN-21934 is a potent, highly selective human topoisomerase II α (Topo IIα) with IC50 of 2 μM for inhibition of DNA relaxation, 100-fold selectivity for topo IIα over Topo β.
ARN-21934 is more potent than the anticancer drug etoposide (IC50=120 uM).
ARN-21934 displays a broad antiproliferative activity toward cultured human cancer cells (DU145, IC50=11.5 uM).
ARN-21934 also exhibits a favorable in vivo pharmacokinetic profile, and the ability to penetrate the blood-brain barrier.
| M.Wt | 360.46 | |
| Formula | C21H24N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N4-[4-(Dimethylamino)phenyl]-5,6,7,8-tetrahydro-2-(4-pyridinyl)-4,6-quinazolinediamine |
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1. Jose Antonio Ortega, et al. J Med Chem. 2020 Nov 12;63(21):12873-12886.
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