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Chemical Structure : ARN-75041
Catalog No.: PC-72616Not For Human Use, Lab Use Only.
ARN-75041 (ARN75041) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 1.7 and 15.3 nM, respectively.
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ARN-75041 (ARN75041) is a potent, small molecule fusion inhibitor of arenavirus, inhibits pseudotyped entry of pGTOV and pCHAPV with EC50 of 1.7 and 15.3 nM, respectively.
ARN-75041 demonstrated sub-nanomolar against native replicative LASV (LASV EC90<0.3 nM) and JUNV (EC90=6.2 nM).
ARN-75041 also potently inhibits mutant T434I pTCRV variant with EC50 of 29 nM.
ARN-75041 dramatically improved survival outcome and potently inhibited TCRV replication in serum and various tissues at doses of 10 and 35 mg/kg, provided highly significant post-exposure protection in mice against TCRV infection.
| M.Wt | 414.549 | |
| Formula | C27H30N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brian B Gowen, et al. Antiviral Res. 2021 Sep;193:105125.
2. Michael B Plewe, et al. Bioorg Med Chem Lett. 2021 Jun 1;41:127983.
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