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Chemical Structure : ARN1468
CAS No.: 1381459-14-8
Catalog No.: PC-49096Not For Human Use, Lab Use Only.
ARN1468 is an anti-prion, cellular active small molecule targeting SERPINA3 (ITC KD=26 uM), decreases prion accumulation and reduces PrPSc in the ScGT1 RML cell line with EC50 of 8.64 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | $898 | In stock | |
| 100 mg | Get quote |
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ARN1468 is an anti-prion, cellular active small molecule targeting SERPINA3 (ITC KD=26 uM), decreases prion accumulation and reduces PrPSc in the ScGT1 RML cell line with EC50 of 8.64 uM.
ARN1468 exhibits anti-prion effect in ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, reduces PrPSc levels by 35% on average, reduces prion levels by almost 85% in ScN2a cells infected with 22L prion.
Anti-prion activity of ARN1468 does not affect PrP petabolism, localization, or aggregation propensity.
ARN1468 and quinacrine act synergically to clear prions in ScN2a RML cells.
| M.Wt | 354.333 | |
| Formula | C16H17F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5-amino-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-4-yl)(piperidin-4-yl)methanone |
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1. Colini Baldeschi A, et al. J Med Chem. 2022 Jun 30. doi: 10.1021/acs.jmedchem.2c00205.
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