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Chemical Structure : ARN19874
CAS No.: 2190502-57-7
Catalog No.: PC-35258Not For Human Use, Lab Use Only.
ARN19874 (ARN-19874) is the first selective, cell-active inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $578 | In stock | |
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| 100 mg | Get quote |
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ARN19874 (ARN-19874) is the first selective, cell-active inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 uM.
ARN19874 displays no inhibitory effect on carbonic anhydrase (CA) II, neutral endopeptidase and angiotensin-converting enzyme (ACE) at 50 uM.
ARN19874 is significantly less potent on the Q320A mutant.
ARN19874 causes a substantial accumulation of non-metabolized NAPE species iuman HEK-293 cells at 50 uM.
| M.Wt | 394.405 | |
| Formula | C19H14N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide |
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1. Castellani B, et al. Chem Commun (Camb). 2017 Nov 28;53(95):12814-12817.
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